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Stefan N Constantinescu Selected Research

Essential Thrombocythemia

7/2021Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms.
1/2020MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491.
1/2020Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development.
1/2020Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms.
1/2020Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN.
12/2019JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera.
1/2019Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice.
1/2019The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.
3/2016Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
1/2016Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.
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Stefan N Constantinescu Research Topics

Disease

30Neoplasms (Cancer)
12/2021 - 04/2005
17Primary Myelofibrosis (Myelosclerosis)
07/2021 - 12/2005
17Essential Thrombocythemia
07/2021 - 12/2005
8Polycythemia Vera
12/2019 - 01/2005
8Alzheimer Disease (Alzheimer's Disease)
12/2019 - 05/2006
7Hypersensitivity (Allergy)
01/2018 - 01/2005
6Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2018 - 08/2008
6Leukemia
12/2015 - 04/2005
5Myeloproliferative Disorders (Myeloproliferative Disorder)
02/2010 - 04/2005
4Hematologic Neoplasms (Hematological Malignancy)
03/2021 - 08/2008
4Thrombocytosis (Thrombocythemia)
01/2019 - 02/2014
3Polycythemia (Erythrocytosis)
01/2018 - 04/2005
3Amyloid Plaque
01/2016 - 03/2008
2COVID-19
01/2022 - 10/2020
2Thrombocytopenia (Thrombopenia)
12/2021 - 11/2019
2Glioblastoma (Glioblastoma Multiforme)
10/2013 - 01/2013
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
12/2005 - 01/2005
1Rheumatic Diseases (Rheumatism)
01/2022
1Congenital amegakaryocytic thrombocytopenia
12/2021
1Lymphopenia (Lymphocytopenia)
10/2020
1Anemia
10/2020
1Hyperplasia
01/2020
1Splenomegaly
01/2020
1Eosinophilia
12/2019
1Rheumatoid Arthritis
01/2018
1Graft vs Host Disease (Graft-Versus-Host Disease)
01/2018
1primary familial and congenital Polycythemia
01/2018
1Inflammation (Inflammations)
01/2018
1Immune System Diseases (Immune Disorders)
01/2018
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2018
1Autoimmune Diseases (Autoimmune Disease)
01/2018
1Glioma (Gliomas)
10/2013
1Polyploidy
09/2010
1Down Syndrome (Down's Syndrome)
11/2008
1Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic)
08/2008
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2008
1T-Cell Lymphoma (Lymphoma, T Cell)
04/2008

Drug/Important Bio-Agent (IBA)

14CalreticulinIBA
12/2021 - 12/2015
12Thrombopoietin ReceptorsIBA
12/2021 - 05/2009
8Janus Kinase 2IBA
06/2021 - 02/2009
8Peptides (Polypeptides)IBA
12/2019 - 03/2008
8Proteins (Proteins, Gene)FDA Link
01/2016 - 12/2005
7Amyloid (Amyloid Fibrils)IBA
12/2019 - 05/2006
7Phosphotransferases (Kinase)IBA
02/2014 - 01/2005
6Thrombopoietin (c-mpl Ligand)IBA
12/2021 - 02/2014
6CytokinesIBA
01/2016 - 01/2005
4Janus Kinase InhibitorsIBA
01/2022 - 06/2011
4ruxolitinibIBA
01/2022 - 06/2011
4Cytokine Receptors (Cytokine Receptor)IBA
12/2019 - 07/2014
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2018 - 10/2005
4Tyrosine (L-Tyrosine)FDA Link
02/2010 - 04/2005
3Biological ProductsIBA
10/2020 - 12/2005
3LigandsIBA
12/2019 - 07/2008
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
12/2019 - 02/2009
3Amino AcidsFDA Link
01/2019 - 04/2005
3ErythropoietinFDA Link
01/2018 - 08/2005
3Janus KinasesIBA
08/2013 - 08/2008
2tofacitinibIBA
01/2022 - 01/2018
2Janus Kinase 3IBA
01/2018 - 11/2015
2Amyloid beta-PeptidesIBA
04/2010 - 03/2008
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
08/2009 - 04/2005
2Valine (L-Valine)FDA Link
06/2007 - 04/2005
2Phenylalanine (L-Phenylalanine)FDA Link
06/2007 - 04/2005
1baricitinibIBA
01/2022
1nezulcitinibIBA
01/2022
1Pharmaceutical PreparationsIBA
07/2021
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2020
1Ferritins (Ferritin)IBA
10/2020
1C-Reactive ProteinIBA
10/2020
1Biomarkers (Surrogate Marker)IBA
10/2020
1eltrombopagFDA Link
01/2020
1Reticulin (Reticular Fiber)IBA
01/2020
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
12/2019
1Interleukin-3 Receptors (Interleukin 3 Receptor)IBA
12/2019
1Linezolid (Zyvox)FDA Link
11/2019
1Anti-Bacterial Agents (Antibiotics)IBA
11/2019
1Oxazolidinones (2 Oxazolidone)IBA
11/2019
1Methotrexate (Mexate)FDA LinkGeneric
01/2018
1Erythropoietin Receptors (Erythropoietin Receptor)IBA
01/2018
1Hydroxyurea (Hydrea)FDA LinkGeneric
01/2018
14,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA
12/2016
1STAT5 Transcription FactorIBA
03/2016
1Interleukin-7 (Interleukin 7)IBA
07/2014
1Cysteine (L-Cysteine)FDA Link
07/2014
1mangion-purified polysaccharide (Candida albicans)IBA
06/2013
1Mitogen-Activated Protein KinasesIBA
01/2013
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2013
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
01/2013
1Proteasome InhibitorsIBA
05/2012
1Adenosine Triphosphate (ATP)IBA
01/2012
1Type C PhospholipasesIBA
10/2011
1MicroRNAs (MicroRNA)IBA
07/2010
1Granulocyte Colony-Stimulating Factor Receptors (G-CSF Receptor)IBA
08/2009
1Interleukin-9 Receptors (Interleukin 9 Receptor)IBA
03/2009
1Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)IBA
07/2008
1InterleukinsIBA
04/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
04/2008

Therapy/Procedure

5Therapeutics
12/2015 - 03/2008
1Precision Medicine
03/2021
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
11/2008